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Saturday, March 2, 2024
HomeHealth Supplements4 Must-Have Benefits Of Threonine

4 Must-Have Benefits Of Threonine


When you think of amino acids, threonine is rarely the first thing that comes to mind. Threonine is one of the nine essential amino acids and contributes to the production of the other amino acids glycine and serine. Research suggests that threonine may benefit several biological events, promoting better sleep, gut health, and muscle contraction. We’ll discuss threonine in more detail, how it works, and what role it plays in your body.

Threonine is an essential amino acid. There are twenty amino acids in total, nine of which are considered essential and the rest are either non-essential or conditional.

Amino acids are the building blocks that the body uses to make proteins. “Essential” amino acids are amino acids that the body cannot produce on its own and must be obtained from dietary sources or supplements.

Threonine is used as a substrate for protein synthesis, especially mucins. Mucins are the most abundant macromolecules in mucus and determine their biochemical and biophysical properties. In addition, threonine can enter catabolic pathways where it can be metabolized to various important products (glycine, acetyl-CoA, pyruvate) that play a vital role in host metabolism (R).

Other studies have shown that threonine can promote growth and enhance protein synthesis in skeletal muscle. Threonine not only serves as a precursor for protein synthesis, but also a signaling molecule that regulates protein synthesis pathways (R).

Essential amino acids are closely related to lipid metabolism. Threonine deficiency has been shown to affect lipid metabolism, triglyceride synthesis, and fat oxidation.

Threonine has been used for a variety of conditions, most related to muscle control or spasticity. Threonine has also been studied for the treatment of multiple sclerosis (MS), a genetic disorder characterized by weakness and stiffness in the legs (familial spastic paraparesis or FSP) and Lou Gehrig’s disease (amyotrophic lateral sclerosis syndrome or ALS). More evidence is needed to support the use of threonine as a treatment for these diseases (R).

A review conducted by the University of Queensland has found that the use of threonine in a multidisciplinary treatment program may contribute to the possible treatment of ALS. Threonine is a glycine precursor that increases glycine levels in the central nervous system. A double-blind, placebo-controlled, crossover study of oral l-threonine in the treatment of spinal spasms found modest antispasmodic effects (R).

Emerging evidence suggests that threonine may cause sleep effects. Studies have found that threonine can increase sleep time and sleep latency by directly stimulating GABA γ-aminobutyric acid. GABA is an inhibitory neurotransmitter that blocks or suppresses certain brain signals in the central nervous system. GABA inhibits excitatory neurons, promoting a sense of calm, relaxation, and anxiolytic effects. It also promotes sleep when GABA receptors are activated. Research shows that GABA can be beneficial in improving mood state, sleep quality, reducing anxiety and lowering blood pressure.

Research shows that threonine plays a vital role in muscle protein synthesis. Threonine can also serve as a precursor or protein synthesis, and as a signaling molecule to regulate protein synthesis pathways.

Insulin-like growth factor I (IGF-I) is an upstream activator of mammalian target of rapamycin (mTOR) in skeletal muscle and is essential for muscle development and regeneration.R).

mTOR is a downstream component of the PI3K/AKT pathway that regulates protein synthesis through ribosomal S6 kinase (S6K) and eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (R). A recent article reported that dietary threonine promotes muscle protein synthesis by activating the PI3K/AKT/TOR signaling cascade via IGF-I (R).

Threonine is an essential amino acid (EAA), which means you’ll find threonine in EAA supplements. We recommend Swolverine’s INTRA as it contains all essential amino acids, added electrolytes and raw whole foods for optimal athletic performance.

Admired: INTRA (Cherry Cream, Tropical 30 Servings)

The gut serves multiple roles, including nutrient absorption and digestion, and immune defense against invading pathogens and toxins. Threonine is utilized by the intestinal mucosa, which contributes to the structural integrity of the gut. Studies have found that threonine may help enhance digestion and absorption in the gut.

Research shows that threonine can improve and create healthy gut flora. Dietary high in threonine has been shown to reduce Salmonella and Escherichia coli (E. coli) colonies while increasing Lactobacillus. In addition, studies have shown that dietary threonine rebalances the gut microbiota of animals under stress (R).

Each essential amino acid contributes to the muscle rebuilding process and has its own unique biological mechanism. Research suggests that threonine may aid gut health, protein synthesis, muscle contraction (cramping), and even promote better sleep. Adding more protein to your diet, along with EAA supplementation in your nutrition/supplementation regimen, are easy ways to get more threonine in your diet to aid exercise and overall health and performance.


Find a Supplement That Contains a Healthy Dose of L-Threonine

inside the car is an advanced intra-workout supplement designed to maximize hydration and enhance training performance during workouts. INTRA is made with proven athletic performance ingredients, antioxidant-rich superfoods and electrolytes. INTRA combines essential amino acids, tart cherry extract, pomegranate, spirulina, coconut water and ginseng for maximum endurance, mental focus, muscle growth, hydration and recovery. Take your performance to unprecedented levels with INTRA.

SWOLVERINE is an endurance athlete and active lifestyle brand. Designed for elite athletes and the strong-minded individual, our products are designed to enhance your athletic performance.us fulfill when you act.

We believe that everyone can not only optimize their athletic ability Performance But their human potential.The way we believe we can optimize performance is by Transparency, clinically effective doses and clinically proven ingredients with evidence-based results. We provide the nutrients you need to fuel an active lifestyle.

walter hinchman

Walter Hinchman is the founder and CEO of Swolverine. He is a NESTA and ACE certified trainer and holds a Masters in Business and Financial Economics.

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