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Monday, March 4, 2024
HomeBody Building SupplementsIntroducing 3rd Generation Curcumin - Supplements and Nutrition - COMMUNITY

Introducing 3rd Generation Curcumin – Supplements and Nutrition – COMMUNITY


The Evolution of Turmeric Supplements

Some forms of curcumin boosted blood levels by a small amount, if any, but the new generation is almost 100 times more powerful.


Very few bodybuilding-slash-health supplements trickle down to get adopted by regular people. There are a few exceptions, of course. Practically every soccer mom has at least heard of creatine.

Turmeric, or rather its active ingredient, curcumin, is another example. You’d be hard-pressed to find a Whole Foods shopper who wasn’t aware of the plant’s anti-bacterial, anti-atherosclerotic, anti-fungal, anti-inflammatory, anti-fat accruing, antioxidant, anti-thrombotic, anti-erectile dysfunction, anti-viral, and anti-communist (I’m assuming) effects.

Turmeric products are legion. Turmeric can be found in skin products that, despite making you temporarily look like a Cheeto, are said to rejuvenate the skin. It’s in teas and digestive aids, and some people even throw the root directly into their protein shakes.

It’s too bad they’re largely wasting their time. Even a lot of the people who’ve graduated to using raw curcumin rather than the root that contains it aren’t doing themselves much good.

Here’s the problem. Turmeric contains too little of its active ingredient (curcuminoids) to do anything except maybe give your stools an initially alarming but ultimately pleasing yellow school bus hue. And even if you do manage to ingest large amounts of raw curcumin, your digestive system goes to great lengths to absorb it and shuttle it off to your body where it can do its magic.

There are several reasons for this. For one, ordinary curcumin isn’t soluble in the acidic pH of the stomach. When it reaches the neutral or alkaline environment of the large intestine, much of it’s converted into inactive waste, a process called glucuronidation, which is how the body rids itself of most drugs and things it considers pollutants.

Even when some of the raw curcumin makes it through the large intestine intact, it’s subjected to further metabolism (breakdown) by the bacteria in the colon. Oh, a small amount eventually does get absorbed into the bloodstream, but much of it gets quickly metabolized by liver cells and unceremoniously excreted through bile.

As evidence, there are several studies, all disturbing, that have chronicled giving patients large amounts of raw curcumin, e.g., 3.6 grams (about 7 capsules), only to discover, an hour or more later, that blood and liver levels of free-form curcumin were almost non-existent.

So yeah, all those poor slobs eating/drinking raw turmeric or non-enhanced curcumin are probably doing themselves little good. Scientists knew this from early on, so they’ve devoted a good deal of time figuring out how to make curcumin the supplement it was supposed to be. It took three generations of curcumin formulations to get it right, though.

First Generation Curcumin

The earliest attempts to improve curcumin’s absorption included the addition of turmeric oil (BCM-95, BioCurcumax, Curcugreen), producing it as oleoresin (Curcugen), or adding a small amount of piperine, an alkaloid present in black pepper. The latter, in fact, was what Biotest used in its early curcumin product (Curcumin 500).

The piperine stimulated the gastrointestinal system, prevented curcumin efflux, and, most importantly, inhibited the hepatic and gastrointestinal glucuronidation described earlier. It roughly increased curcumin absorption 20-fold over raw, unmodified curcumin.

The result of this curcumin/piperine alliance was a measurable improvement in bioavailability and safety, significantly reducing delayed onset muscle soreness. It also led to anti-arthritic and even anti-diabetic effects, decreased oxidative stress, and reduced DNA damage. Most importantly, it teased at what curcumin could ultimately be, if bioavailability could somehow be enhanced further.

Second Generation Curcumin

As described earlier, curcumin is hydrophobic. Water scares the bejesus out of it. Throw a scoop of it into a glass of water and it just floats there.

The natural response was to enhance curcumin’s solubility and bioavailability by combining it with fats – polysorbates, phospholipid complexes, liquid droplet nano micelles, and spray drying.

These second-generation formulations, Meriva among them, showed excellent bioavailability and proved to be anti-arthritic, anti-diabetic, and anti-viral in various clinical studies, along with improving the survival rates of cancer patients, supporting ulcerative colitis patients, and even having pro-sexual effects (raising testosterone levels).

While the first-generation curcumin formulations improved the bioavailability of raw curcumin by approximately 20-fold, these second-generation curcumins were reported to have 27 times the bioavailability of pure curcumin. Quite an achievement, but clearly, there was still room for improvement.

Third Generation Curcumin

The newest curcumin formulations increase the bioavailability of “free” curcuminoids (the active polyphenol constituents found in curcumin) without using synthetic polysorbates and/or emulsifiers employed in the previous generation.

Further, they contain no adulterants, which makes them safer, i.e., nongenotoxic and nonhepatotoxic (safe for the liver). Most impressively, they’ve increased curcumin bioavailability by 100 times over that of raw curcumin.

To be blunt, comparing first-generation curcumins (or, worse yet, turmeric teas and various products) to this third-gen tech is like comparing early, unmanned sub-orbital spaceflight to the Apollo missions that landed on the moon. Or, in a more modern example, first gen curcumin products are like Ask Jeeves, while 3rd-gen products are closer to ChatGPT.

Some of these new 3rd-gen varieties employ a curcumin/galactomannan (a polysaccharide derived from the cell walls of fungi) alliance or a complex of curcumin and fenugreek galactomannan (a polysaccharide from the cell walls of the herb, fenugreek).

Biotest, however, chose to go with a lecithin/curcumin complex invented by neuroscientists at UCLA and patented as Longvida Optimized Curcumin®, sold by Biotest as Micellar Curcumin. The formulation is termed a “solid lipid curcumin complex.” It elegantly survives initial hydrolysis and delivers free curcumin and its metabolites to the brain and throughout the body via the lymphatic system.

Take a single dose and high levels of curcumin are detected in the bloodstream within one hour. Furthermore, high levels are detected as long as 24 hours later, suggesting that one daily dose is all you need for round-the-clock protection.

And none of this is theoretical. More than 50 review papers involving humans have found Longvida’s Optimized Curcumin® offers a host of tangible health benefits, including, but not limited to, eye and neural health support, healthy aging, joint health, reproductive health, gut health, and mood and cognitive health, along with possibly having beneficial effects in the prevention or treatment of various diseases.

In short, it does all the things the earlier generations of curcumin delivery systems hinted at, only a lot better.

Furthermore, Longvida Optimized Curcumin® holds several certifications and accreditations within the industry from third-party organizations dedicated to upholding quality and promoting elite standards within the natural products industry. These include the following:

  • Non-GMO
  • Meets or Exceeds USP/ICH/Prop-65 Standards
  • Certified Glyphosate Residue Free
  • Self-GRAS Affirmation
  • Informed Choice Informed-Sport Compliant
  • WADA (World Anti-Doping Agency) Compliant
  • C-14 Testing Compliant
  • National Animal Supplement Council Approved/Compliant

Clearly, we’re in a brave new curcumin world, and those us of in this world can only take pity on those still using turmeric root or raw curcumin delivery systems. They’ll learn soon enough, I suppose, but I wonder how many negative health conditions might have been side-stepped if these unsuspecting users of turmeric or raw curcumin had kept abreast of the new technology.

Metabolic Drive Metabolism Boosting / Award-Winning Protein

Biotest

References

References

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