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Monday, March 4, 2024
HomeHealth SupplementsSermorelin: Benefits, Uses, Side Effects

Sermorelin: Benefits, Uses, Side Effects


Sermorelin, is a synthetic or man-made peptide. It’s what’s known as a growth hormone secretagogue. Growth hormone secretagogue’s are a class of drugs, which induce the secretion of growth hormone. GH secretagogues are being used as an alternative to growth hormone replacement therapy and have been found to have great use in longevity and aging. We’re going to talk more about what sermorelin is, what it does, how it works, and the benefits of this growth hormone inducing peptide.

Sermoerlin, also known as growth hormone releasing factor 1–29 NH2-acetate, is a growth hormone secretagogue, that induces the natural release of growth hormone. It’s a 29 amino acid polypeptide.

Sermorelin, is an analog of naturally occurring growth hormone-releasing hormone (GHRH), whose activity declines as we age. Sermorelin, had been commercially marketed and used in children who needed help with growth, however, it could not compete with a therapeutic alternative to Growth hormone replacement therapy (GHRT) using recombinant human growth hormone (rhGH).

Children need higher doses of growth hormone, to induce significant changes, that can be achieved by stimulating a hormone of their own production, thus it has been found to be a greater benefit in aging adults.

Unlike exogenous growth hormone, that causes the production of insulin like growth factor-1 (IGF-1) from the liver, sermorelin stimulates the pituitary gland to induce and increase the production of endogenous human growth hormone.

Since sermorelin naturally increases human growth hormone and is not exogenously applied the effects of sermorelin are naturally regulated by the negative feedback loop. 

Your pituitary gland endogenously releases hGH in short bursts (pulses) or in a pulsatile manner, throughout the day. The release of hGH is mainly controlled by two hormones your hypothalamus releases: growth hormone-releasing hormone (GHRH), which stimulates hGH release, and somatostatin, which prevents or (inhibits) hGH release.

IGF-1 plays a critical role in preventing (inhibiting) the release of the hGH through what’s called the negative feedback loop by stimulating somatostatin and inhibiting GHRH release. hGH and IGF-1 secretion are regulated by each other, where hGH triggers IGF-1 release, and the IGF-1 inhibits hGH release in a feedback loop. Thus, they are antagonists, yet complementary to one another.

Male hypogonadism is when the body produces little to no hormones. This can greatly affect body composition, despite training protocols, and nutritional intervention. Obesity and metabolic syndrome can both cause and result from hypogonadism.

Sermorelin, is a potent GH and IGF-1 stimulator that can significantly improve body composition while ameliorating specific hypogonadal symptoms including fat gain and muscular atrophy.

Although testosterone replacement therapy is the gold standard for hypogonadism, or the decline in hormonal levels as we age, sermorelin and other growth hormone secretagogue, can help increase lean body mass and reduce body fat.

Sermorelin has been found to have significant clinical benefit, in age management. Optimizing growth hormone and hormonal levels, can improve overall mood state, as well as energy, and improve the aging process.

The decline in growth hormone as we age, is associated with reductions in lean body mass, strength, increases in body fat, and declines of cognitive function and memory. Deep (slow-wave) sleep also decreases markedly with age, together with a decrease in nighttime growth hormone secretion, and sleep disorders can become a significant problem.

Several studies have shown that growth hormone-releasing hormones restores normal GH pulsatility and amplitude, selectively reduces visceral fat, intima media thickness and triglycerides, and improves cognitive function in older persons (R).

Therapeutic dosage has not been determined. However, studies typically show that sermorelin increases hGH in a dose dependent manner (R), with conventional doses ranging between 1mg and 2mg per day. 

For growth deficiency, data suggests that daily subcutaneous injections of sermorelin 30 microg/kg bodyweight is effective in promoting growth in some prepubertal children with idiopathic growth hormone deficiency (R).

Sermorelin is generally very well tolerated, with a great safety profile. General side effects are caused by or interact at the injection site, and can result in

  • Skin irritation
  • Redness
  • Swelling
  • Itching
  • Acute pain

HGH peptides or secretagogues, interact with the hypothalamus and pituitary gland to naturally increase and facilitate the production of GH levels in the body. These peptides do work, however are they safe to take. They do not have the same risks associated with testosterone replacement therapy (TRT), or HGH; in relation to the reduction in sperm count, joint pain, swelling, or increased insulin resistance.

Peptides do not shut down your own testosterone production, thus will not disrupt fertility. However, peptides should be cycled and prescribed by a physician. The long-term safety and efficacy of GH-releasing peptides is not well studied. Even though GH-releasing peptides may be helpful for several indications or conditions when prescribed by a healthcare provider, off-label use of GH-releasing peptides is not safe or recommended.

Before taking any peptides, we do advise consulting a physician for specific recommendations. Peptides do need to be prescribed by a physician, to ensure quality and efficacy standards.

There have been no human pharmacokinetic or metabolic studies, to show potential risk factors or side effects to date.

Disclaimer: Swolverine does not condone the use or sell steroidal, non-steroidal SARMS, anabolic agents, pro-hormones, or peptides. The contents of this article are for informational purposes only. Sermorelin is not for sale in the United States and used for only investigational use. Possessing, using, or distributing these substances may lead to serious legal consequences. Off label use is prohibited to clinical setting. Sermorelin and other peptides are on the WADA prohibited banned substance list and will cause a failed drug test.


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